Long-term Efficacy and Safety of Fixed-combination Timolol/Latanoprost

The fixed-combination preparation of timolol and latanoprost has been available in Europe since 2001. Evidence supporting its level of clinical efficacy has been slowly accumulating, with some studies suggesting clear benefit and others showing only a modest additional effect relative to its individual components. Studies demonstrating long-term protection of visual function are sparse and more work is required in this area. Several reports indicate that fixed-combination timolol/latanoprost is safe and well tolerated. Other similar combination products are now competing directly with fixed-combination timolol/latanoprost, and further comparative studies will be required to assess their relative merits.